Daniel A Erlanson: search on Z-Library

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1

Design principles for fragment libraries – Maximizing the value of learnings from Pharma fragment based drug discovery (FBDD) programs for use in academia

Keseru, Gyorgy M, Erlanson, Daniel Andrew, Ferenczy, Gyorgy G, Hann, Michael M., Murray, Christopher W, Pickett, Stephen D.

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.19 MB

english, 2016

2

Twenty years on: the impact of fragments on drug discovery

Erlanson, Daniel A., Fesik, Stephen W., Hubbard, Roderick E., Jahnke, Wolfgang, Jhoti, Harren

Journal:

Nature Reviews Drug Discovery

Year:

2016

Language:

english

File:

PDF, 3.52 MB

english, 2016

3

[Methods and Principles in Medicinal Chemistry] Fragment-based Approaches in Drug Discovery (JAHNKE: FRAGMENT-BASED APPROACHES IN DRUG DISCOVERY O-BK) || Fragment-based Lead Discovery and Optimization Using X-Ray Crystallography, Computational Chemistry, and High-throughput Organic Synthesis

Jahnke, Wolfgang, Erlanson, Daniel A.

Year:

2006

Language:

english

File:

PDF, 732 KB

english, 2006

4

Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery

Daniel A. Erlanson, Joseph W. Arndt, Mark T. Cancilla, Kathy Cao, Robert A. Elling, Nicki English, Jessica Friedman, Stig K. Hansen, Cathy Hession, Ingrid Joseph, Gnanasambandam Kumaravel, Wen-Cherng

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 843 KB

english, 2011

5

Facile synthesis of cyclic peptides containing di-, tri-, tetra-, and pentasulfides

Daniel A. Erlanson, James A. Wells

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 245 KB

english, 1998

6

Allosteric inhibition of protein tyrosine phosphatase 1B

Wiesmann, Christian, Barr, Kenneth J, Kung, Jenny, Zhu, Jiang, Erlanson, Daniel A, Shen, Wang, Fahr, Bruce J, Zhong, Min, Taylor, Lisa, Randal, Mike

Journal:

Nature Structural and Molecular Biology

Year:

2004

Language:

english

File:

PDF, 1.16 MB

english, 2004

7

The leucine zipper domain controls the orientation of AP-1 in the NFAT·AP-1·DNA complex

Daniel A. Erlanson, Milan Chytil, Gregory L. Verdine

Journal:

Chemistry & Biology

Year:

1996

Language:

english

File:

PDF, 7.90 MB

english, 1996

8

[Methods and Principles in Medicinal Chemistry] Fragment-based Approaches in Drug Discovery (JAHNKE: FRAGMENT-BASED APPROACHES IN DRUG DISCOVERY O-BK) || Click Chemistry for Drug Discovery

Jahnke, Wolfgang, Erlanson, Daniel A.

Year:

2006

Language:

english

File:

PDF, 763 KB

english, 2006

9

[Methods and Principles in Medicinal Chemistry] Fragment-based Approaches in Drug Discovery (JAHNKE: FRAGMENT-BASED APPROACHES IN DRUG DISCOVERY O-BK) || Tethering

Jahnke, Wolfgang, Erlanson, Daniel A.

Year:

2006

Language:

english

File:

PDF, 484 KB

english, 2006

10

[Methods and Principles in Medicinal Chemistry] Fragment-based Approaches in Drug Discovery (JAHNKE: FRAGMENT-BASED APPROACHES IN DRUG DISCOVERY O-BK) || The Concept of Fragment-based Drug Discovery

Jahnke, Wolfgang, Erlanson, Daniel A.

Year:

2006

Language:

english

File:

PDF, 89 KB

english, 2006

11

[Methods and Principles in Medicinal Chemistry] Fragment-based Approaches in Drug Discovery (JAHNKE: FRAGMENT-BASED APPROACHES IN DRUG DISCOVERY O-BK) || Location of Binding Sites on Proteins by the Multiple Solvent Crystal Structure Method

Jahnke, Wolfgang, Erlanson, Daniel A.

Year:

2006

Language:

english

File:

PDF, 308 KB

english, 2006

12

[Methods and Principles in Medicinal Chemistry] Fragment-based Approaches in Drug Discovery (JAHNKE: FRAGMENT-BASED APPROACHES IN DRUG DISCOVERY O-BK) || Entropic Consequences of Linking Ligands

Jahnke, Wolfgang, Erlanson, Daniel A.

Year:

2006

Language:

english

File:

PDF, 139 KB

english, 2006

13

[Methods and Principles in Medicinal Chemistry] Fragment-based Approaches in Drug Discovery (JAHNKE: FRAGMENT-BASED APPROACHES IN DRUG DISCOVERY O-BK) || Pyramid: An Integrated Platform for Fragment-based Drug Discovery

Jahnke, Wolfgang, Erlanson, Daniel A.

Year:

2006

Language:

english

File:

PDF, 327 KB

english, 2006

14

[Methods and Principles in Medicinal Chemistry] Fragment-based Approaches in Drug Discovery (JAHNKE: FRAGMENT-BASED APPROACHES IN DRUG DISCOVERY O-BK) || Ligand SAR Using Electrospray Ionization Mass Spectrometry

Jahnke, Wolfgang, Erlanson, Daniel A.

Year:

2006

Language:

english

File:

PDF, 249 KB

english, 2006

15

[Methods and Principles in Medicinal Chemistry] Fragment-based Approaches in Drug Discovery (JAHNKE: FRAGMENT-BASED APPROACHES IN DRUG DISCOVERY O-BK) || Dynamic Combinatorial Diversity in Drug Discovery

Jahnke, Wolfgang, Erlanson, Daniel A.

Year:

2006

Language:

english

File:

PDF, 397 KB

english, 2006

16

[Methods and Principles in Medicinal Chemistry] Fragment-based Approaches in Drug Discovery (JAHNKE: FRAGMENT-BASED APPROACHES IN DRUG DISCOVERY O-BK) || Multivalency in Ligand Design

Jahnke, Wolfgang, Erlanson, Daniel A.

Year:

2006

Language:

english

File:

PDF, 566 KB

english, 2006

17

[Methods and Principles in Medicinal Chemistry] Fragment-based Approaches in Drug Discovery (JAHNKE: FRAGMENT-BASED APPROACHES IN DRUG DISCOVERY O-BK) || Synergistic Use of Protein Crystallography and Solution-phase NMR Spectroscopy in Structure-based Drug Design: Strategies and Tactics

Jahnke, Wolfgang, Erlanson, Daniel A.

Year:

2006

Language:

english

File:

PDF, 303 KB

english, 2006

18

[Methods and Principles in Medicinal Chemistry] Fragment-based Approaches in Drug Discovery (JAHNKE: FRAGMENT-BASED APPROACHES IN DRUG DISCOVERY O-BK) || NMR-guided Fragment Assembly

Jahnke, Wolfgang, Erlanson, Daniel A.

Year:

2006

Language:

english

File:

PDF, 605 KB

english, 2006

19

[Methods and Principles in Medicinal Chemistry] Fragment-based Approaches in Drug Discovery (JAHNKE: FRAGMENT-BASED APPROACHES IN DRUG DISCOVERY O-BK) || Fragment Docking to Proteins with the Multi-copy Simultaneous Search Methodology

Jahnke, Wolfgang, Erlanson, Daniel A.

Year:

2006

Language:

english

File:

PDF, 433 KB

english, 2006

20

[Methods and Principles in Medicinal Chemistry] Fragment-based Approaches in Drug Discovery (JAHNKE: FRAGMENT-BASED APPROACHES IN DRUG DISCOVERY O-BK) || Structural Fragments in Marketed Oral Drugs

Jahnke, Wolfgang, Erlanson, Daniel A.

Year:

2006

Language:

english

File:

PDF, 198 KB

english, 2006

21

[Methods and Principles in Medicinal Chemistry] Fragment-based Approaches in Drug Discovery (JAHNKE: FRAGMENT-BASED APPROACHES IN DRUG DISCOVERY O-BK) || Cheminformatics Approaches to Fragment-based Lead Discovery

Jahnke, Wolfgang, Erlanson, Daniel A.

Year:

2006

Language:

english

File:

PDF, 254 KB

english, 2006

22

[Methods and Principles in Medicinal Chemistry] Fragment-based Approaches in Drug Discovery (JAHNKE: FRAGMENT-BASED APPROACHES IN DRUG DISCOVERY O-BK) || Index

Jahnke, Wolfgang, Erlanson, Daniel A.

Year:

2006

Language:

english

File:

PDF, 45 KB

english, 2006

23

[Methods and Principles in Medicinal Chemistry] Fragment-based Approaches in Drug Discovery (JAHNKE: FRAGMENT-BASED APPROACHES IN DRUG DISCOVERY O-BK) || Front Matter

Jahnke, Wolfgang, Erlanson, Daniel A.

Year:

2006

Language:

english

File:

PDF, 119 KB

english, 2006

24

[Methods and Principles in Medicinal Chemistry] Fragment-based Approaches in Drug Discovery (JAHNKE: FRAGMENT-BASED APPROACHES IN DRUG DISCOVERY O-BK) || SAR by NMR: An Analysis of Potency Gains Realized Through Fragment-linking and Fragment-elaboration Strategies for Lead Generation

Jahnke, Wolfgang, Erlanson, Daniel A.

Year:

2006

Language:

english

File:

PDF, 344 KB

english, 2006

25

Fragment-Based Drug Discovery.

Daniel A. Erlanson, Robert S. McDowell, Tom O'Brien

Journal:

Year:

2004

File:

PDF, 48 KB

2004

26

Falling out of the fold: tumorigenic mutations and p53

Daniel A. Erlanson, Gregory L. Verdine

Journal:

Chemistry & Biology

Year:

1994

Language:

english

File:

PDF, 3.58 MB

english, 1994

27

Discovery of an Aurora kinase inhibitor through site-specific dynamic combinatorial chemistry

Mark T. Cancilla, Molly M. He, Nina Viswanathan, Robert L. Simmons, Meggin Taylor, Amy D. Fung, Kathy Cao, Daniel A. Erlanson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 266 KB

english, 2008

28

Making drugs on proteins: site-directed ligand discovery for fragment-based lead assembly

Daniel A Erlanson, Stig K Hansen

Journal:

Current Opinion in Chemical Biology

Year:

2004

Language:

english

File:

PDF, 529 KB

english, 2004

29

Fragment-based lead discovery: a chemical update

Daniel A Erlanson

Journal:

Current Opinion in Biotechnology

Year:

2006

Language:

english

File:

PDF, 1.12 MB

english, 2006

30

The advantages of ambiguous orientation

Daniel A Erlanson

Journal:

Chemistry & Biology

Year:

2000

Language:

english

File:

PDF, 129 KB

english, 2000

31

Relations between the penetration, binding and average concentration of cytostatic drugs in human tumour spheroids

Martin Erlanson, Erika Daniel-Szolgay, Jörgen Carlsson

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1992

Language:

english

File:

PDF, 3.02 MB

english, 1992

32

Selective base-pair destabilization enhances binding of a DNA methyltransferase

Daniel A. Erlanson, Scot A. Wolfe, Lin Chen, Gregory L. Verdine

Journal:

Year:

1997

Language:

english

File:

PDF, 829 KB

english, 1997

33

Mast cell infiltration is a favourable prognostic factor in diffuse large B-cell lymphoma

Gustaf Hedström, Mattias Berglund, Daniel Molin, Marie Fischer, Gunnar Nilsson, Ulf Thunberg, Majlis Book, Christer Sundström, Richard Rosenquist, Göran Roos, Martin Erlanson, Rose-Marie Amini, Gunill

Journal:

British Journal of Haematology

Year:

2007

Language:

english

File:

PDF, 480 KB

english, 2007

34

Long term risk of infections in Hodgkin lymphoma long-term survivors

Anne Andersson, Gunilla Enblad, Anita Gustavsson, Martin Erlanson, Hans Hagberg, Daniel Molin, Björn Tavelin, Beatrice Melin

Journal:

British Journal of Haematology

Year:

2011

Language:

english

File:

PDF, 64 KB

english, 2011

35

In situ assembly of enzyme inhibitors using extended tethering

Erlanson, Daniel A., Lam, Joni W., Wiesmann, Christian, Luong, Tinh N., Simmons, Robert L., DeLano, Warren L., Choong, Ingrid C., Burdett, Matthew T., Flanagan, W. Michael, Lee, Dennis

Journal:

Nature Biotechnology

Year:

2003

Language:

english

File:

PDF, 1.22 MB

english, 2003

36

Early and intermediate stage Hodgkin's lymphoma – report from the Swedish National Care Programme

Daniel Molin, Gunilla Enblad, Anita Gustavsson, Tor Ekman, Martin Erlanson, Eva Haapaniemi, Bengt Glimelius

Journal:

European Journal of Haematology

Year:

2003

Language:

english

File:

PDF, 319 KB

english, 2003

37

Tethering in early target assessment

Johan D Oslob, Daniel A Erlanson

Journal:

Drug Discovery Today: TARGETS

Year:

2004

Language:

english

File:

PDF, 795 KB

english, 2004

38

Tethering: Fragment-Based Drug Discovery

Erlanson, Daniel A., Wells, James A., Braisted, Andrew C.

Journal:

Annual Review of Biophysics and Biomolecular Structure

Year:

2004

Language:

english

File:

PDF, 683 KB

english, 2004

39

Selective Reduction of Peptide Isothiazolidin-3-ones

Shiau, Timothy P., Erlanson, Daniel A., Gordon, Eric M.

Journal:

Organic Letters

Year:

2006

Language:

english

File:

PDF, 137 KB

english, 2006

40

Allosteric Inhibition of PTP1B Activity by Selective Modification of a Non-Active Site Cysteine Residue †

Hansen, Stig K., Cancilla, Mark T., Shiau, Timothy P., Kung, Jenny, Chen, Teresa, Erlanson, Daniel A.

Journal:

Year:

2005

Language:

english

File:

PDF, 379 KB

english, 2005

41

Fragment-Based Drug Discovery

Erlanson, Daniel A., McDowell, Robert S., O'Brien, Tom

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 324 KB

english, 2004

42

Validity of Ligand Efficiency Metrics

Murray, Christopher W., Erlanson, Daniel A., Hopkins, Andrew L., Keserü, György M., Leeson, Paul D., Rees, David C., Reynolds, Charles H., Richmond, Nicola J.

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 441 KB

english, 2014

43

Learning from our mistakes: The ‘unknown knowns’ in fragment screening

Davis, Ben J., Erlanson, Daniel A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 748 KB

english, 2013

44

The Orientation of the AP-1 Heterodimer on DNA Strongly Affects Transcriptional Potency

Milan Chytil, Blake R. Peterson, Daniel A. Erlanson and Gregory L. Verdine

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.67 MB

english, 1998

45

A Structural Snapshot of Base-Pair Opening in DNA

Daan M. F. Van Aalten, Daniel A. Erlanson, Gregory L. Verdine and Leemor Joshua-Tor

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.59 MB

english, 1999

46

Disulfide Cross-linking as a Mechanistic Probe for the B ↔ Z Transition in DNA

Erlanson, Daniel A., Glover, J. N. Mark, Verdine, Gregory L.

Journal:

Journal of the American Chemical Society

Year:

1997

Language:

english

File:

PDF, 141 KB

english, 1997

47

Body weight loss, reduced urge for palatable food and increased release of GLP-1 through daily supplementation with green-plant membranes for three months in overweight women

Montelius, Caroline, Erlandsson, Daniel, Vitija, Egzona, Stenblom, Eva-Lena, Egecioglu, Emil, Erlanson-Albertsson, Charlotte

Journal:

Year:

2014

Language:

english

File:

PDF, 840 KB

english, 2014

48

Discovery of a New Phosphotyrosine Mimetic for PTP1B Using Breakaway Tethering

Erlanson, Daniel A., McDowell, Robert S., He, Molly M., Randal, Mike, Simmons, Robert L., Kung, Jenny, Waight, Andrew, Hansen, Stig K.

Journal:

Journal of the American Chemical Society

Year:

2003

Language:

english

File:

PDF, 208 KB

english, 2003

49

DNA methylation through a locally unpaired intermediate

Erlanson, Daniel A., Chen, Lin, Verdine, Gregory L.

Journal:

Journal of the American Chemical Society

Year:

1993

Language:

english

File:

PDF, 1.33 MB

english, 1993

50

Fragment-Based Ligand Discovery Meets Phage Display

Erlanson, Daniel A.

Journal:

ACS Chemical Biology

Year:

2007

Language:

english

File:

PDF, 258 KB

english, 2007